After the 341 meeting is there any reason the debt won’t be discharged?

It depends. 

The 341 meeting happens pretty quickly after a case is filed and well before any deadlines to object to an entry of a discharge in your case have run. So, if there is a reason for a creditor to object to your discharge before the 341 meeting, that reason still exists after the meeting. Once the deadline - set at 60 days after the first date set for the meeting of creditors - passes, your discharge will be granted and your debt eliminated (assuming it’s dischargeable in bankruptcy). 

You can also inadvertently give the bankruptcy trustee a new reason to object to your discharge or - worse yet - cause the trustee to ask the bankruptcy court to revoke your discharge. It’s the one sword the trustee holds over the bankruptcy filer to ensure continued cooperation in the administration of the case. If you stop responding to inquiries from the trustee or refuse to turn over a nonexempt asset, you’re risking your bankruptcy discharge. That’s why it’s so important to keep the court and your trustee updated if your contact information changes even after your discharge has been entered.